![]() ![]() More Awesome Kindergarten Graduation Gift Ideas They’ll love revealing the colors underneath the black surface, and parents will appreciate the mess-free creativity. Rainbow Scratch Art Set – A rainbow scratch art set is a fun and creative way for kids to express themselves.They’ll love digging in the dirt and watching their plants grow. Kids’ Gardening Set – A gardening set designed for kids is a great way to teach them about the natural world and develop a love of gardening.They’ll love taking pictures of everything they see, and parents will love the ability to preserve memories. Kids’ Digital Camera – A digital camera designed for kids is a great way to encourage their love of photography.They can experiment with water and objects, develop fine motor skills, and enjoy some summer fun. Water Table – A water table is a fun and interactive way for kids to play outside.They’ll love the colorful blocks and the ability to build whatever they want. ![]()
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![]() ![]() Moreover, the detection of some biofilm related genes in these strains and their involvement with biofilm will be evaluated. So, the aim of the present study was to investigate the biofilm forming ability of Staphylococcus strains causing bovine mastitis using different phenotypic methods. According to our knowledge, in Egypt, researches on biofilm only began recently and mainly focused on Staphylococcus clinical isolates from human sources. Monitoring the biofilm forming ability of Staphylococci causing mastitis and the genes involved in it may provide new ideas or strategy for the prevention or the effective treatment of bovine mastitis. The intercellular adhesion ( ica) locus consisting of the genes icaADB and C encodes the proteins mediating the synthesis of PIA and PS/A in staphylococcal species. Then, the bacteria multiply to form a multilayered biofilm, which was associated with production of polysaccharide intercellular adhesin (PIA). Firstly, the bacteria adhere to a surface mediated by a capsular antigen, namely, capsular polysaccharide/adhesin (PS/A). It is considered to be a two-step process. Staphylococcus biofilm formation mechanisms are complex and include the participation of many kinds of proteins, and so many genes are involved. The ability of Staphylococci to form biofilms is one of the virulence factors that facilitate the adherence and colonization of Staphylococci on the mammary gland epithelium, also contributing to the evasion of the immunological defences and to the difficulty of pathogen eradication, leading to recurrent or persistent infections. īiofilm is an exopolysaccharide, a slime matrix around multiple layers of cells. The pathogenesis of Staphylococcus mastitis is attributed to a combination of extracellular factors and properties such as adherence and biofilm formation. aureus and coagulase negative Staphylococci (CNS) remains a substantial problem for milk producers worldwide. Therefore, attention must be paid toward implementation of new ways for effective treatment of such infections.īovine mastitis caused by S. This study demonstrated high prevalence of Staphylococcus biofilm producers among bovine mastitis in Egypt. Presence of icaA and icaD genes was not always correlated with biofilm production. The eno gene had the highest rate while the bap gene had the lowest rate. aureus isolates, the positive rates of eno, icaA, icaD, and bap genes were 75%, 15%, 62.5%, and 2.5% while in CNS were 92.6%, 5.9%, 47.1%, and 4.4%, respectively. All isolates were screened for presence of biofilm related genes, eno, icaA, icaD, and bap. Indian ink staining was used to detect the EPS layer of biofilm producers. aureus isolates were strong, moderate, and weak biofilm producers, while in CNS the percentages were 44%, 30.9%, and 19.2%, respectively. By microtiter plate (MTP) method, 52.5%, 27.5%, and 20% of S. aureus strains were strong, intermediate, and negative biofilm producers, while in CNS the percentages were 29.5%, 42.6%, and 27.9%, respectively. aureus and 68 coagulase negative Staphylococcus (CNS) isolates from bovine subclinical mastitis were investigated for their ability to form biofilm as one of the most important virulence factors.Using Congo Red Agar (CRA) method, 32.5%, 35%, and 32.5% of S. Although the patient was given polyvalent human immunoglobulins (IgG, IgA, and IgM levels were normal: 7.3 g/L, 2.34 g/L, and 0.17 g/L, respectively), the long-term immunosuppressive therapy caused severe TCD4 + lymphopenia (0.064 × 10 9/L) and was instrumental in allowing the infection and dissemination of the yeast.A total of 40 S. Treatment with associating high doses of amphotericin B and flucytosine was quickly started, but the patient died 10 days later.Ĭryptococcus neoformans infection is rare among immunocompetent patients. BM examination suggested the diagnosis that was confirmed by additional tests. Disseminated cryptococcosis caused by Cryptococcus neoformans was confirmed by India ink stain and a cryptococcal antigenemia test was run on the cerebrospinal fluid. BM examination revealed no signs of dysmegakaryopoiesis or plasma cell invasion, but there were several histiocytes with intracellular encapsulated bodies identified as fungal cells. Complete blood count readings showed mild anemia (hemoglobin 105 g/L), normal white blood cell count (7.8 × 10 9/L) with severe lymphopenia (0.15 × 10 9/L), and severe thrombocytopenia (41 × 10 9/L), which prompted a bone marrow (BM) aspiration. After 3 relapses, she was treated with a combination of corticosteroids, cyclophosphamide, and pomalidomide and was believed to be in complete remission. Her International Staging System stage III MM had been diagnosed incidentally 8 years prior. A 77-year-old white woman who was followed for an IgA-λ multiple myeloma (MM) was admitted for the development of neurological symptoms. ![]() ![]() ![]() You can find Klarna's Terms & Conditions on. If you have additional questions or need help regarding your payment, please contact Klarna's customer service. Please note that H&M is unable to provide further details if you're not eligible to pay using our H&M x Klarna services. Update your card details for your Pay in 4 purchases.Īdditional details about Klarna's payment methods and how to use them online and in-store can be found here. Would like to return an item? If you report your return, your invoice from Klarna will be put on hold until your return is handled. Need more time to pay? Postpone your due date, a small cost may apply (possible for Pay later and Pay in 4 interest-free installments). View all your purchases and pay your invoices all at once or at a scheduled time. ![]() On October 21, 2020, PayPal announced a new service allowing customers to. You can view information about all of your H&M x Klarna purchases in My Account. is an American multinational financial technology company operating an. CA resident loans made or arranged pursuant to a California Financing Law license. Our latest Global Impact Report features ESG strategies, activities, progress, metrics, and performance in calendar year 2022 across four core dimensions: Employees & Culture, Social Innovation, Responsible Business. A higher initial payment may be required for some consumers. Our environmental, social, and governance (ESG) strategy is a critical part of how we drive long-term business value and growth. The three remaining payments will be deducted every 14 days from your first payment. The first payment is taken when your order ships. The installments are automatically deducted from your card. Shop now and spread the cost into 4 interest-free payments. ![]() After your purchase is registered, Klarna will send you an email with your payment information. United States and Canada Phone Numbers Languages and Hours (877) 815-1531 (toll free) +1 (415) 395-4225 English, Spanish and Filipino. Just activate Pay later in the H&M app and scan your membership QR-code at checkout. CA resident loans made or arranged pursuant to a California Financing Law license.Īs soon as your online order has been shipped, you will receive an email from Klarna with information on how to submit your payment. You can shop, try on items at home, and only pay for what you keep. With Pay later, H&M members get up to 30 days to pay. The options that are available to you will be presented at checkout. H&M x Klarna payment methods are available online and in-store exclusively for H&M members. Klarna is a trusted payment service provider that offers consumers flexible methods to afford their purchases. Comfortable elegance: online exclusives. ![]() ![]() ![]() This is a relatively small price to pay compared to the doubled incoming damage and lack of healing that comes with other fleeces, and four cards is usually enough to give you a significant advantage. Complacent Gaming Syndrome: The Fleece of Fates is a fairly safe choice for any dungeon, giving you four Tarot cards at the start of each crusade at the cost of not being able to pick up anymore afterwards. ![]() Breather Level: During Crusades, there is always a chance that any given combat room will only contain a handful of weak enemies.Awesome Music: One of the most praised aspects of the game is its haunting soundtrack, fitting the vibe of the cultist aspect of the game.Awesome Art: The art style is regularly touted as a highlight of the game, being very colorful and cute to look at.Angst? What Angst?: While it's meant to set up the backdrop of the story and establish why the Lamb was chosen to be a servant of The One Who Waits, the Lamb doesn't seem too broken up about the fact that their unseen family and potentially friends were genocided so that the prophecy couldn't be fulfilled.If you choose to have the Lamb indoctrinate The One Who Waits, rather than killing him, is the Lamb doing it to show he's not like him and wants to show him a better way of being a leader and making others happy? Or is it a form of Cruel Mercy where the Lamb is surpassing his cruelty by ruling over him with the same power he's lost and will never again have?.Considering he mugs the Lamb for 2/3rds of their current gold stash during a random encounter in the post game campaign, it's probably more pragmatism than fear. ![]() Does he do it out of genuine gratitude and honor towards them? Or is it simply to ensure that the Lamb keeps helping him and/or because he's afraid that they will otherwise kill him? ![]()
![]() ![]() Original image by Christian Holmér.If you are also an Android user and the quality of your camera has become bad, especially in low-light conditions. So know how you can install Google Camera on your Android phone to capture great pictures even from old phones. Let us tell you that Google Camera is also known as GCam APK. Skip step 3 to create an "inside out" planet photo that looks like you're lying on the ground looking up at the sky. ![]() Shoot your panorama at night to give the effect of a planet floating in space. Include buildings right up to the foreground to make a densely populated planet photo. Use a photo with varied terrain to create a jagged asteroid effect. Here are a few examples showing what's possible when you combine this technique with a little bit of creativity and imagination. If you come across any interesting variations then please share them in the comments. You can produce some fantastic effects by experimenting, so don't feel you have to stick rigidly to the above instructions. Re-crop your image and you're done!Ĭreating little planet photos is extremely easy once you get the hang of it. This will leave white corners, but you can fill those with the same colour you used for the gradient. If you'd prefer your planet to be a different way round, now is the time to rotate it. Use the Clone Stamp or Healing Brush to fix any problems. Voilà ! Your panorama is now wrapped into a circle and looks like a little planet photographed from above using a fisheye lens.Ĭheck the upper centre of your photo to make the sure things look smooth where the panorama's edges were joined. Make sure "Rectangular to Polar" is selected and hit "OK". Go to Filter > Distort > Polar Coordinates. This ensures it wraps the right way when we turn it into a planet. Use Image > Image Rotation > 180° to flip your image upside down. Set the left-hand opacity slider to 100% and the right-hand one to 0%.ĭrag a gradient from the top of your photo downwards a little distance, to produce a smooth transition to the solid colour. Select the gradient tool and set the left and right colour sliders to match the dominant sky colour. Ths step is optional but will prevent the corners of the final image looking stretched and warped. This will squash your image and make it look distorted. Uncheck "Constrain Proportions" and set the height to match the width. Make the image squareīecause of the way stereographic projections are made, we need to start with a square image. I'll be using the following photo which you can download here if you want to follow along. If you're struggling to find a suitable photo then there tons freely available under the Creative Commons licence, such as this selection on Flickr. If in doubt, give it a go - breaking the above "rules" can sometimes lead to weird and wonderful effects that you wouldn't have got otherwise, so don't be afraid to experiment. This might sound like a lot of criteria to meet, but you'll find that the majority of panoramas will be suitable. If yours don't then you can easily rotate and re-crop in Photoshop. The horizon - This needs to be perfectly level so the edges of the picture meet neatly. As with the sky, a flat colour or simple texture such as grass, sand or water looks best. The ground - The bottom of your photo will be squashed together to form the centre of the planet, and this can lead to some extreme distortion. A clear sky tends to produce the best results, although clouds can give an interesting, stretched effect. The sky - Your panorama's sky will be severely distorted in the final image. Wider images tend to produce smoother planet surfaces, while narrower panoramas give more height variation. Image width - The aspect ratio (width divided by height) of your photo affects how smooth the planet looks. Narrower angles can work but you might need to do some work to match colours and textures where the edges meet. The viewing angle - 360 degree panoramas work best because their edges line up perfectly, making for a seamless planet photo. Here are the things you need to consider: Virtually any panorama can be turned into a little planet photo, but certain images tend to work better than others. Turn your panoramas into eye-catching miniature planets. I'll be using Photoshop in this example but you can do it in most graphics programs, including GIMP, which is free. The technical name for this technique is "stereographic projection" but don't let the name put you off - it's very simple to do and only takes 5 minutes. This little tip adds an extra pinch of creativity, turning standard panoramas into miniature planets that really have the "wow" factor. They contain so much interest and detail that they practically beg you to explore them. Panoramas are one of my favourite ways to show off a scene. ![]() ![]() ![]() And at least HBO Max offers an app on the Mac, unlike most video streaming services out there. Once installed, open HBO Max and sign in. Then, select HBO Max and choose the download option. All PCs running Windows 7 or later should load HBO Max. Open the App Store on your Apple device and search for HBO Max. The result is a “full screen” app that’s locked to the iPad’s 4:3 display orientation, meaning that while you can make the video playback bigger, it’s still going to be pillarboxed inside an old-school non-widescreen aspect ratio. All Chromebooks appear to be supported, while HBO notes that Mac support is limited to devices running macOS 10.10 Yosemite or later. macOS 11.1 does finally allow apps like HBO Max to go to full-screen, eliminating a major limitation. When I went to the HBO Max website and chose the Apple TV icon as my provider, it says I do not have have a subscription to HBO through Apple TV, which is not true. Follow the installation instructions you will find in the application file. ![]() macOS 11.1 also allows iPhone and iPad app windows to be switched between landscape and portrait orientations. There is no app to download for the MacBook apparently. How to install HBO Max on your PC We provide you with both the HBO Max APK file and the BlueStacks emulator that will allow you to run the application on your PC: Download and unzip the file containing both the HBO Max APK and the BlueStacks emulator files. Also know, how do I download HBO to my Mac Use the PlayOn Cloud app to download your HBO Max movies or shows to your iPad, iPhone, Android phone/tablet, or computer to watch from anywhere. Keying off of the release of macOS Big Sur 11.1 Monday, Joe Rossignol at MacRumors wrote:Īnother notable change mentioned in the update’s release notes is the ability for iPhone and iPad apps with non-resizable windows to enter full-screen mode on Macs with the M1 chip, which is particularly useful for video apps like HBO Max. Choose the episode or film that you want to download, most are available on HBO Max but those that aren’t won’t have the ‘download’ button option. HBO Max is only accessible in certain territories. Some titles and features shown above may not be available in your country. Content and feature availability on HBO Max may vary by region. Up to five viewer profiles with customizable profile images. Behold, the majesty of HBO Max in full-screen mode on an M1 Mac Download episodes and movies to your phone or tablet to watch offline, anytime. ![]() ![]() ![]() Our books are distributed in the region by John Wiley & Sons Ltd. The European office also works with members of the University Press Group, who look after sales throughout Europe. The digital and audio publisher is also based in Europe and oversees the Press’s audio list. The majority of our translation rights are handled through the European office, and we visit publishers and attend book fairs from this location. ![]() Among its biggest sellers have been the newly recorded works of. Our publicity team is in touch with media across Europe as well as the Penguin Random House appointed him as its first audio publisher last September, and will produce more than 300 titles this year. Our European editors cover the humanities, social sciences, and sciences, and travel widely throughout the continent. Well take your retail-ready title and deliver it to 50+ sales channelsfrom major retailers such as iTunes, Audible, and Amazon, to boutique platforms, streaming services, and libraries worldwideensuring your work has the widest distribution available Step 4. Originally consisting of three people, the European office has now grown to fifteen, encompassing editorial, audio and translation rights, and publicity. Sell your audiobook everywhere with one simple system. Its presence has given us the opportunity to expand the Press’s scholarly connections and visibility in Europe through the expansion of our author pool and through the increased media coverage and sales we are able to achieve. The European office of Princeton University Press celebrated its twentieth anniversary in 2019. ![]() ![]() ![]() It’s a low-pressure pump aimed squarely at fat tire types, so if you’re looking for a pump that will do double duty with skinny tires, there are better options. Thanks to its fat (508-cc) aluminum barrel, this thing does, in fact, push out a whole lot of air with relatively few strokes. In truth, my success rate in getting those tubeless beads to pop satisfyingly into place is about 50/50, but a lot of that also boils down to the tire and rim combo in question. ![]() So very fast, in fact, that you are supposed to easily seat tubeless tires with the thing. The Air Tool MTB is designed to inflate tires fast. It ticks off all the boxes that actually matter. This model-the Air Tool MTB-sits right in the middle of the range and makes the most sense for most mountain bikers. Specialized / are no fewer than nine Air Tool floor pumps in the Specialized line for 2016-there are ultra-high pressure models for the skinny-tire set, shiny, polished aluminum models that probably look good in a garage, nestled next to some mid-life-crisis-edition sports car and bare-bones budget models for Top Ramen aficionados on the other end of the economic spectrum. It’s only after a couple more seasons that you look back and realize, “Shoot, this thing is actually kind of awesome because I’m still using it and I don’t really want to use anything else anymore.” That, right there, sums up my experience with this floor pump, the Air Tool MTB, which retails for $80 and is worth every damn cent of it. Instead, it just quietly goes about its business. Sometimes you buy something, use it for a season and think, “This thing is alright.” It doesn’t automatically rocket to the top of your “best thing ever” list, per se. ![]() ![]() ![]() So while you could see the previous player’s high score if they didn’t reset it, the game’s use of a high score system was largely meant to incentive you to do better than your personal best rather than leave a record of your accomplishments for all future players to see. ![]() However, that system meant that a high score could actually become too high to beat, rendering the bonus round unobtainable unless the score (and the personal high score process) was reset. What kind of sick joke is that? Who would ever want to erase a high score? Well, if players can beat their high score within an allotted time, they get to play a short bonus round to make their Sea Wolf score climb even higher. However, the cabinet also features a prominent button that erased the current record. The game only recorded one high score at a time, and if a player beat that mark, the game replaces the old high score with a new one. While Sea Wolf was the first game to introduce the concept of a “high score,” its developers had a very different notion of what that term should mean (at least in terms of how we now think of high scores). Players needed to look through the periscope to view the crosshairs needed to line up shots, while onlookers could still watch the action unfold on the main screen. That incredibly simple concept was thematically enhanced by Sea Wolf‘s periscope-shaped controller. The faster the ship, the more points players receive if they hit it. The only real goal in the game was to shoot torpedoes at different ships. Like many arcade titles at the time, Sea Wolf relied on a pretty basic premise. The first video game to ever use the term “high score” was Midway’s 1976 arcade cabinet, Sea Wolf. While there are a few titles that are arguably worthy of that honor depending on how you choose to define the concept, each of those games iterated on the basic idea of a high score and eventually morphed it into the trope we know and love today. ![]() That raises the obvious question of which game actually used high scores first. Not only did many early games not feature tracked scoring systems, but it actually took quite some time for the industry to invent the concept of the high score as we typically define it today. Whatever form they take, modern games typically allow some way for players to upload and save their score for all to see. After all, what is a speedrun but a competition that turns clear times into ranked scores? While high scores aren’t quite as popular as they once were, the spirit of that concept lives on today in various forms. Some players devote their lives to perfecting runs that maximize their in-game points. To some hardcore gamers, acquiring an all-time high score is serious business. To be fair, many gamers love inserting quarters into arcade cabinets, outperforming rival players, and recording their scores after each session. The idea of playing a game to achieve a high score is one of those concepts that wormed its way into our pop-culture consciousness around the time that gaming itself reached the mainstream. Regardless, all modern video game scores and scoring mechanics stem from older titles and the fabled concept of the “high score.” Even games that don’t feature obvious scoring systems are usually secretly judging players (the Metroid series would reward players with different conclusions depending on how quickly they completed the game). Titles such as Devil May Cry 5 use scores to judge a player’s ability to weave together different attacks, while Tetris uses scores as a measure of a player’s critical thinking skills and ability to plan ahead. 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